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CA Cancer J Clin 1998;48:629. Dev Biol 274, 308317. Monotherapy, Copharmacy, and Polypharmacy As emphasized in Chapter 1, a major principle of drug therapy is the value of monotherapy (i. (1980). 4 Gianni Paganini, by ingenious textual archaeology, has demonstrated that some of Hobbess ideas trace a direct line of descent from Lorenzo Valla through Erasmus, who had read and annotated Vallas Elegantiae at the age of eighteen, and who discovered and published Vallas Adnotationes in Novum Testamen- tum in 1505;5 and finally.

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